Measured NAD+ elevation
A single 500 mg NR infusion raised whole blood NAD+ more than 20% above baseline within three hours — ahead of both the NAD+ IV comparator and oral NR in the same study.
Advanced Wellness · Brentwood, Tennessee
A pharmaceutical-grade nicotinamide riboside infusion, administered on site by the Care Nashville clinical team. Niagen delivers NR — the vitamin B3 compound your cells convert into NAD+ — directly into circulation, bypassing the digestive losses that limit oral capsules.
$500 per 500 mg infusion
Niagen® IV is a pharmaceutical-grade intravenous form of nicotinamide riboside (NR), a vitamin B3 compound that cells convert into NAD+ through two enzymatic steps. Because it is infused rather than swallowed, it is not subject to stomach acid, first-pass liver metabolism, or the labeled daily ceiling on oral NR. In a 2024 randomized, placebo-controlled pilot study, a single 500 mg NR infusion raised whole blood NAD+ by more than 20% within three hours.
Both are studied for the same target — cellular NAD+. They take different routes to get there, and the difference shows up in the chair.
| Niagen® NR IV | NAD+ IV | |
|---|---|---|
| What is infused | Nicotinamide riboside, an NAD+ precursor | The NAD+ molecule itself |
| How cells take it up | Enters cells intact via nucleoside transporters, then converts in two steps | Largely broken down outside the cell before uptake |
| Reported infusion time | Substantially shorter — the pilot trial recorded a mean tolerable infusion time 75% below NAD+ IV | Commonly a multi-hour appointment |
| Infusion experience in the trial | Fewer and less severe experiences than NAD+ IV; mouth tingling, mild congestion and ear pressure were noted | Participants reported more frequent and more intense infusion-related experiences |
| Niacin-type flushing | NR does not act on the GPR109A pathway associated with nicotinic acid flushing | Not a flush mechanism, but chest tightness and cramping are frequently described |
Comparison reflects published pilot trial data in generally healthy adults. Individual experience varies.
Niagen IV is unusual among infusion add-ins: there is a published human trial behind it. Here is what it measured — and, just as importantly, what it did not.
A single 500 mg NR infusion raised whole blood NAD+ more than 20% above baseline within three hours — ahead of both the NAD+ IV comparator and oral NR in the same study.
Mean tolerable infusion time for NR IV was 75% less than for the NAD+ IV arm — a meaningful difference when you are scheduling around a Nashville workday.
No attributable adverse events were reported through the 14-day follow-up period in any treatment group, and no significant differences in vital signs were detected across groups.
The study followed a single acute infusion in a small group of generally healthy adults. It did not track energy, sleep, cognition, body composition, or any longevity outcome, and it was not designed to. NAD+ elevation is a biomarker, not a promise of how you will feel. Please review the research with a qualified healthcare provider before drawing conclusions from it.
Niagen is a single-compound add-in rather than a broad vitamin blend, so it tends to suit people whose goal is specifically cellular NAD+ — not general hydration or nutrient repletion.
NAD+ consumption climbs with age while the salvage enzymes that recycle it slow down. Supplying NR gives those pathways raw material to work with.
Labeled oral intake tops out at 300 mg per day, and what you swallow still has to survive digestion. An infusion is bound by neither constraint.
Nausea, cramping, and chest tightness are commonly described with NAD+ infusion. The pilot trial recorded a milder infusion experience with NR.
Chronic stress and disrupted sleep both accelerate NAD+ drawdown through DNA repair and inflammatory signaling — a familiar pattern in our Brentwood and Nashville patient base.
Often discussed alongside our other IV therapy options when volume rather than age is the driver.
Some pair it with peptide therapy or ozone therapy. Our clinical team will tell you plainly when layering does not make sense.
Talk with your healthcare provider first if you are pregnant or breastfeeding, managing a liver or kidney condition, or have a known sensitivity to any infusion component. Our clinical team reviews your history before any infusion is scheduled.
We review your goals, current supplements, medications, and relevant labs. If Niagen is not the right fit, we will say so and walk you through the alternatives.
Niagen can be administered on its own or alongside an existing drip. Cadence is set with your clinician rather than pulled from a menu.
You are seated in our Brentwood suite with a member of the clinical team present throughout. Reported chair time for NR is materially shorter than a standard NAD+ drip.
We check in on tolerance and how you are tracking, then adjust the plan — including stopping it — based on what you actually report.
Care Nashville is led by Dr. Donald Vollmer and Dr. Hemal Mehta. Infusion protocols are reviewed by our clinical team, not handed off to a menu.
Niagen is administered in our Brentwood office with clinical oversight and your history on file — which matters more with a single-compound infusion than with plain hydration.
We cite the trial, name the sample size, and tell you what it did not measure. If a therapy is early, you will hear that from us before you book it.
Our Brentwood location is minutes from Cool Springs and Franklin and a short drive down I-65 from Green Hills, Belle Meade, and downtown Nashville.
Nicotinamide riboside occurs naturally in milk, yeast extract, and beer, but only in trace amounts. Niagen is the patented, pharmaceutical-grade form of NR chloride — a vitamin B3 compound cells convert into NAD+ through two enzymatic steps. Dietary intake alone comes nowhere near the amounts used in cellular health research.
NR enters circulation the moment the infusion begins. In the 2024 pilot trial, whole blood NAD+ peaked more than 20% above baseline around the three-hour mark. Oral capsules have to clear stomach acid and first-pass liver metabolism before any NR reaches the bloodstream, so peak timing here is measured in hours rather than days. What that biomarker change means for how you feel was not an endpoint of the study.
NAD+ is a large molecule that is largely broken down outside the cell before it can be taken up. NR enters cells intact and is converted to NAD+ internally. In the pilot trial, the NR arm showed a higher whole blood NAD+ response, fewer and less severe infusion-related experiences, and a mean tolerable infusion time 75% shorter than the NAD+ arm.
NR does not activate the GPR109A pathway responsible for the flushing associated with nicotinic acid, which is what separates it from niacin. Trial participants did describe mild, transient sensations — tingling in the mouth, slight congestion, a bit of ear pressure — and nothing severe surfaced across the 14-day follow-up.
Considerably less than a standard NAD+ drip. The manufacturer reports infusion time roughly 75% shorter, consistent with the mean tolerable infusion time recorded in the trial. Your exact chair time depends on the protocol your clinician sets and whether Niagen is paired with another infusion. Our Brentwood team will give you a realistic window when you book.
Many patients do. Labeled oral NR intake caps at 300 mg daily and is subject to digestive losses; an infusion is bound by neither. Bring your current supplement list to your consultation so the clinical team can review the combination with your full history.
Speak with a healthcare provider before scheduling if you are pregnant or breastfeeding, managing a liver or kidney condition, or have a known sensitivity to any infusion component. The published trial enrolled generally healthy adults, so it does not speak to these situations. Care Nashville reviews your medical history before scheduling any infusion.
A 500 mg Niagen® NR infusion is $500 at Care Nashville in Brentwood. That covers the infusion itself, administered by our clinical team. An initial consultation is required before your first infusion, and any additional drips or add-ins are priced separately. We will give you the full figure before you book, not after.
Care Nashville offers Niagen® NR IV therapy at our Brentwood, Tennessee clinic, serving patients from Nashville, Franklin, Cool Springs, Green Hills, and the surrounding Middle Tennessee area. Call (615) 591-1965 or request a consultation online.
$500per infusion
Pricing is for the Niagen® infusion itself. An initial consultation is required before your first infusion, and any additional infusions or add-ins are priced separately. Prices are current as of this page's last update and subject to change.
Start with a conversation. Our clinical team will review your history, walk through what the research does and does not show, and tell you honestly whether this is worth your time.
Medical disclaimer: This page is provided for general educational purposes and is not medical advice, diagnosis, or treatment. Niagen® is a registered trademark of Niagen Bioscience, Inc. Statements on this page have not been evaluated by the U.S. Food and Drug Administration. Nicotinamide riboside is not intended to diagnose, treat, cure, or prevent any disease. Research findings described here come from a small pilot study in generally healthy adults and may not apply to you. Individual responses vary. Always consult a qualified healthcare provider before beginning any new therapy.
